Research findings, 'The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma,' are discussed in a new report. "The inositol 1,4,5-trisphosphate receptor (InsP3R) mediates Ca(2+) signaling in epithelia and regulates cellular functions such as secretion, apoptosis and cell proliferation. Loss of one or more InsP3R isoform has been implicated in disease processes such as cholestasis," scientists writing in the journal Cell Calcium report (see also Colon Cancer).
"Here we examined whether gain of expression of InsP3R isoforms also may be associated with development of disease. Expression of all three InsP3R isoforms was evaluated …
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